The unseeded Khachanov struck 31 winners in an imperious performance, denying the 14-time grand slam champion a record-equalling 33rd Masters title with a 7-5 6-4 upset in Bercy.
Federer won 28/29 first serves, saved the only break point he faced, and took full advantage of the fast courts to attack the front of the court with plenty of success.
He won the final by 7-5 6-4.
Djokovic will return to No. 1 in the rankings for the first time in two years on Monday, but the Serb will be disappointed at missing out on a 73rd career title, having withstood the best of Federer on Saturday.
Four-time victor Novak Djokovic edged Swiss veteran Roger Federer in full sets in a spotlight semifinal duel to set up his encounter against unseeded Russian Karen Khachanov at the ATP Paris Masters here on Saturday. At the end of a one-sided first set, he complained to Khachanov about the over-zealous reactions of the Russian's camp at courtside.
No8 in the Race, Dominic Thiem, could do no more: He beat Paris's defending champion Jack Sock in a fine three-set comeback, 4-6, 6-4, 6-4. He deserves it. He's a young player up and coming. So if I'm not playing really, really good like today, then what's happening, they kill me', said Thiem who will play the ATP Finals in London next. "I mean, match by match I was increasing my level", said the 22-year-old Khachanov.
The Russian fully demonstrated his confidence later on, finishing quadruple breaks for a 6-1 second set victory. I'm just pleased to be in the semis. Federer is two wins shy of his 100th career title.
A far tougher test lies in store for Federer, however, with Djokovic up next and on a 21-match winning run as he bids for a fourth consecutive title.
In their 47th meeting, the reigning Wimbledon and US Open champion beat Federer 7-6, 5-7, 7-6.
"I don't want to talk about that".
Khachanov became the third different first-time victor of a Masters tournament this season - joining Juan Martin del Potro and John Isner - and will rise to a career-high ranking of 11th on Monday. "And I told him to tell him to keep it down a little bit because he was going a little bit too much over the edge". But already, an established player, top player.
Khachanov has also won two ATP World Tour titles in 2018 with triumphs in Marseille and at the Kremlin Cup.
Marcus Rashford scored a dramatic injury-time victor as Manchester United came from behind to beat in-form Bournemouth . The Red Devils are already 9 points behind with early pacesetter Manchester City with their title dreams all but over.
The EU says 12 consecutive reports from the International Atomic Energy Agency show that Iran has stuck to the terms of the deal. India and South Korea were also on the list, said a source familiar with the matter who spoke on condition of anonymity.
Despite surging output, concerns lingered ahead of the start of U.S. sanctions against Iran's petroleum exports from next week. One is high oil prices, and in many countries they're directly related to consumer prices.
In response, Grande subtweeted Davidson, writing, "For somebody who claims to hate relevancy u sure love clinging to it huh". Davidson performed at a benefit show in Los Angeles last month and joked to the crowd, "Anybody looking for a roommate?"
Rescue teams, including more than 70 salvage vessels, underwater drones and floating cranes, were sent to the site. In response, the driver takes a hand off the steering wheel and grapples with the woman for a couple of seconds.
Oil markets have been anticipating the sanctions for months and the world's biggest producers have been increasing output. Over the weekend, European diplomats continued to discuss another measure, the Special-Purpose Vehicle (SPV).
Iranian students stormed the embassy shortly after the 1979 Islamic Revolution, taking 52 Americans hostage for 444 days. Similarly, Secretary Mnuchin said a list of banks subject to the new sanctions would also be provided on Monday.
Xi also said he and Trump expressed hopes to expand bilateral trade cooperation, Xi was quoted as saying on CCTV state television. Kudlow believes that an economic downturn in China will have "very modest effect" on the US economy and small businesses.
West Texas Intermediate (WTI) crude futures fell 86 cents to settle at $66.18 a barrel, a 1.28 percent drop . President Donald Trump thinks "a great deal" with China is possible on trade.
Breeders' Cup Classic glory for Accelerate
Godolphin have won some big races this year including the Derby with Masar. "They looked good for a mile", Baffert said. The day was a curtainraiser to Saturday's nine-race slate featuring the $4 million Turf and the $6 million Classic.
Andrew Lincoln to Return in Multiple Walking Dead Movies
The British actor's departure was confirmed earlier this year and fans have been waiting to see how Rick would be written out. A viewer said: "Gotta give a shoutout to Andrew Lincoln for beautifully portraying Rick Grimes for over 8 years".
Rona and Lowe's stores to close in northeastern Ontario
However, customers still shop online for truck delivery or parcel shipping, or place a pick-up order for another location. Lowe's said is expects to close the impacted stores by the end of the company's 2018 fiscal year - February 1, 2019.
Alec Baldwin arrested in alleged parking dispute punch
Sophia Mason said of the encounter, "It looks like it was a dispute over the parking spot, and the person in custody punched him". In case you've forgotten, Baldwin's anger has always been a source of news regarding the mediocre Trump impressionist.